Local Anesthetics
Each of the local anesthetics have the suffix "-caine" in their names.
- procaine
- amethocaine
- cocaine
- lidocaine (also known as Lignocaine)
- prilocaine
- bupivacaine
- levobupivacaine
- ropivacaine
- mepivacaine
- dibucaine
Local anesthetics are agents that prevent transmission of nerve impulses without causing unconsciousness. They act by binding to fast sodium channels from within (in an open state). Local anesthetics can be either ester or amide based.
Ester local anesthetics (e.g., procaine, amethocaine, cocaine) are generally unstable in solution and fast-acting, and allergic reactions are common.
Amide local anesthetics (e.g., lidocaine, prilocaine, bupivicaine, levobupivacaine, ropivacaine, mepivacaine and dibucaine) are generally heat-stable, with a long shelf life (around 2 years). They have a slower onset and longer half-life than ester anesthetics, and are usually racemic mixtures, with the exception of levobupivacaine (which is S(-) -bupivacaine) and ropivacaine (S(-)-ropivacaine). These agents are generally used within regional and epidural or spinal techniques, due to their longer duration of action, which provides adequate analgesia for surgery, labor, and symptomatic relief.
Only preservative-free local anesthetic agents may be injected intrathecally.
Read more about this topic: Anesthetic
Famous quotes containing the word local:
“America is the world’s living myth. There’s no sense of wrong when you kill an American or blame America for some local disaster. This is our function, to be character types, to embody recurring themes that people can use to comfort themselves, justify themselves and so on. We’re here to accommodate. Whatever people need, we provide. A myth is a useful thing.”
—Don Delillo (b. 1926)