AFL may refer to:
- American Federation of Labor, one of the first federations of labor unions in the United States, and now part of the AFL-CIO
- American Football League (a.k.a. "AFL IV") - a professional American football league that started competition in 1960, and merged with the National Football League (NFL) in 1970
- Arena Football League, an American indoor football league
- Australian Football League
AFL may also refer to:
Read more about AFL: Other Sports Leagues, Other