Evolution
Although the two isozymes (ALDH1 and ALDH2) do not share a common subunit, the homology between the human ALDH1 and ALDH2 proteins is 66% at the coding nucleotide level and 69% at the amino acid level, which is found to be lower than the 91% homology between human ALDH1 and horse ALDH1. Such a finding is consistent with evidence suggesting the early evoluationary divergence between cytosolic and mitochondrial isozymes, as seen in the 50% homology between pig mitochondrial and cytosolic asparatate aminotransferases.
Read more about this topic: Acetaldehyde Dehydrogenase
Famous quotes containing the word evolution:
“Like Freud, Jung believes that the human mind contains archaic remnants, residues of the long history and evolution of mankind. In the unconscious, primordial “universally human images” lie dormant. Those primordial images are the most ancient, universal and “deep” thoughts of mankind. Since they embody feelings as much as thought, they are properly “thought feelings.” Where Freud postulates a mass psyche, Jung postulates a collective psyche.”
—Patrick Mullahy (b. 1912)
“As a natural process, of the same character as the development of a tree from its seed, or of a fowl from its egg, evolution excludes creation and all other kinds of supernatural intervention.”
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“The more specific idea of evolution now reached is—a change from an indefinite, incoherent homogeneity to a definite, coherent heterogeneity, accompanying the dissipation of motion and integration of matter.”
—Herbert Spencer (1820–1903)