Acetaldehyde Dehydrogenase

Acetaldehyde Dehydrogenase

Acetaldehyde dehydrogenases (EC 1.2.1.10) are dehydrogenase enzymes which catalyze the conversion of acetaldehyde into acetic acid. The oxidation of acetaldehyde to acetate can be summarized as follows:

CH₃CHO + NAD+ + CoA → acetyl-CoA + NADH + H+

In humans, there are three known genes which encode this enzymatic activity, ALDH1A1, ALDH2, and the more recently discovered ALDH1B1 (also known as ALDH5). These enzymes are members of the larger class of aldehyde dehydrogenases.

The CAS number for this type of the enzyme is .