Zp3

ZP3

Identifiers Symbols ZP3; ZP3A; ZP3B; ZPC; Zp-3 External IDs OMIM: 182889 MGI: 99215 HomoloGene: 5178 GeneCards: ZP3 Gene

Gene Ontology
Molecular function	• signal transducer activity • manganese ion transmembrane transporter activity • protein binding • store-operated calcium channel activity • carbohydrate binding • acrosin binding
Cellular component	• acrosomal vesicle • outer acrosomal membrane • proteinaceous extracellular matrix • extracellular space • cytoplasm • multivesicular body • endoplasmic reticulum • Golgi apparatus • plasma membrane • integral to membrane • secretory granule • extracellular matrix • perinuclear region of cytoplasm
Biological process	• positive regulation of type IV hypersensitivity • blastocyst formation • humoral immune response mediated by circulating immunoglobulin • positive regulation of leukocyte migration • positive regulation of humoral immune response • manganese ion transport • intracellular protein transport • binding of sperm to zona pellucida • positive regulation of phosphatidylinositol biosynthetic process • positive regulation of interferon-gamma production • positive regulation of interleukin-4 production • intracellular signal transduction • egg coat formation • positive regulation of T cell proliferation • positive regulation of protein kinase activity • negative regulation of transcription, DNA-dependent • positive regulation of transcription, DNA-dependent • phosphatidylinositol-mediated signaling • oocyte development • positive regulation of inflammatory response • positive regulation of protein kinase B signaling cascade • protein kinase C signaling cascade • manganese ion transmembrane transport • positive regulation of calcium ion import • positive regulation of acrosome reaction • negative regulation of binding of sperm to zona pellucida • positive regulation of acrosomal vesicle exocytosis • positive regulation of ovarian follicle development • positive regulation of antral ovarian follicle growth
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 7784 22788 Ensembl ENSG00000188372 ENSMUSG00000004948 UniProt P21754 P10761 RefSeq (mRNA) NM_001110354.1 NM_011776.1 RefSeq (protein) NP_001103824.1 NP_035906.1 Location (UCSC) Chr 7:
76.03 – 76.07 Mb Chr 5:
135.98 – 135.99 Mb PubMed search

Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) or the sperm receptor, is a protein that in humans is encoded by the ZP3 gene. ZP3 is the receptor in the zona pellucida which binds sperm at the beginning of fertilization.