Yeshe is a Tibetan term meaning wisdom and is analogous to jnana in Sanskrit.

Yeshe may also refer to:

  • Lamrim Yeshe Nyingpo, Vajrayana Buddhist sacred scripture that records oral teachings of Padmasambhava in the 9th century
  • Lobsang Palden Yeshe (1738–1780), the Sixth Panchen Lama of Tashilhunpo Monastery in Tibet
  • Lobsang Yeshe (1663–1737), the 5th Panchen Lama of Tibet
  • Nubchen Sangye Yeshe (9th century), one of the twenty-five principal students of Guru Padmasambhava
  • Thubten Yeshe (1935–1984), Tibetan lama who, while exiled in Nepal, co-founded Kopan Monastery
  • Yeshe De, (Jnanasutra), a Tibetan Vajrayana Dzogchenpa who was a disciple of Sri Singha
  • Yeshe Dorje (1676–1702), the eleventh Gyalwa Karmapa, head of the Kagyu School of Tibetan Buddhism
  • Yeshe Losal Rinpoche, a lama in the Kagyu school of Tibetan Buddhism, abbott of the Samye Ling Monastery, Scotland
  • Yeshe Tsogyal (757–817), a semi-mythical female deity or figure of enlightenment (dakini) in Tibetan Buddhism
  • Yeshe Walmo, deity of the Bon sect of Tibetan Buddhism