Yazoo may mean:
- Yazoo tribe, a Native American people who lived in Mississippi
- Yazoo (language)
- Yazoo River, in the state of Mississippi
- Yazoo stream, a type of floodplain tributary
- Yazoo lands, historic area in Mississippi and Alabama, formerly occupied by Yazoo tribe
- Yazoo land scandal
- Yazoo County, Mississippi
- Yazoo City, Mississippi
- Yazoo Delta Railroad
- Yazoo Brewing Company, a brewery in Nashville, Tennessee
- Yazoo/Kees (originally Yazoo Manufacturing Company), a maker of lawn mowers owned by Husqvarna
- Yazoo (band), a 1980s English pop band, known as Yaz in the United States
- Yazoo (drink), a flavoured milk drink made by Campina
- Yazoo Records
- Yazoo, a character from Final Fantasy VII Advent Children