Yaguchi (矢口, lit. arrow mouth?) is a Japanese surname. Notable people with the surname include:
- Mari Yaguchi, a Japanese pop singer
- Masaki Yaguchi, guitarist for the Japanese rock band called Mucc
- Shinobu Yaguchi, a Japanese film director and screenwriter
- Yoko Yaguchi, a Japanese actress, and the wife of Japanese filmmaker Akira Kurosawa for 39 years
- Yukihiko Yaguchi, a Japanese car designer
- Yutaka Yaguchi, a martial artist
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