WSPA may refer to:
- World Society for the Protection of Animals, an international non-profit animal welfare organisation
- Western States Petroleum Association
- World Student Press Agency, a Canadian student news agency
- Winston-Salem Preparatory Academy, a public school in Forsyth County, North Carolina, United States
- WSPA-TV, a television station (channel 7 digital) licensed to Spartanburg, South Carolina, United States
- WSPA-FM, a radio station (98.9 FM) licensed to Spartanburg, South Carolina, United States
- WOLI (AM), a radio station (910 AM) licensed to Spartanburg, South Carolina, United States, which used the call sign WSPA prior to October 2005