WSB may refer to:
- WSB (AM), a radio station (750 AM) licensed to Atlanta, Georgia, United States
- WSB-FM, a radio station (98.5 FM) licensed to Atlanta, Georgia, United States
- WSB-TV, a television station (virtual channel 2/digital 39) licensed to Atlanta, Georgia, United States
- WSBB-FM, a radio simulcast of WSB-AM (95.5 FM) licensed to Doraville, Georgia, United States
- WSB TV Tower
- William S. Burroughs, a writer
- World Series Baseball, a video game series published by Sega
- Superbike World Championship, often referred to as World SuperBike
- World Security Bureau, a fictional intelligence agency on the daytime soap opera General Hospital
- Weak stability boundary, a Low energy transfer that allows spacecraft to change orbits using very little fuel
- White Star Buff, Color
- Waldschlösschenbrücke
- World Series Boxing