Molecular Biology
Mutations of the WT1 gene on chromosome 11 p 13 are observed in approximately 20% of Wilms' tumors. At least half of the Wilms' tumors with mutations in WT1 also carry mutations in CTNNB1, the gene encoding the proto-oncogene beta-catenin.
A gene on the X chromosome, WTX, is inactivated in up to 30% of Wilms' tumor cases, according to research published in 2007.
Most cases do not have mutations in any of these genes.
Read more about this topic: Wilms' Tumor
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