William Bruce may refer to:
- Sir William Bruce, 1st Baronet, of Balcaskie (c. 1630–1710), Scottish architect
- William Bruce, 8th Earl of Kincardine (1710–1740), Scottish nobleman
- William Bruce (cricketer) (1864–1925), Australian cricketer
- William Bruce (Canadian politician) (d. 1838), physician and politician in Upper Canada
- William Bruce (VC) (1890–1914), posthumous recipient of the Victoria Cross
- William Cabell Bruce (1860–1946), author and United States Senator
- Major William Bruce-Gardyne of Clan Gardyne, Laird of Middleton, Angus, Scotland
- William Speirs Bruce (1867–1921), Scottish explorer
- William George Bruce (1856-1949), Milwaukee publisher, historian, and civic leader
Famous quotes containing the word bruce:
“The liberals can understand everything but people who don’t understand them.”
—Lenny Bruce (1925–1966)