Delayed Wallerian Degeneration
Mice belonging to the strain C57BL/Wlds have delayed Wallerian degeneration, and, thus, allow to study the roles of various cell types and the underlying cellular and molecular processes. Current understanding of the process has been possible via experimentation on the Wlds strain of mice. The mutation occurred first in mice in Harlan-Olac, a laboratory producing animals the United Kingdom. The Wlds mutation is an autosomal-dominant mutation occurring in the mouse chromosome 4. The gene mutation is an 85-kb tandem triplication, occurring naturally. The mutated region contains two associated genes: nicotinamide mononucleotide adenlyl transferase 1 (Nmnat-1) and ubiquitination factor e4b (Ube4b). A linker region encoding 18 amino acids is also part of the mutation. The protein created, localizes within the nucleus and is undetectable in axons.
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