VX may refer to:

  • VX (nerve agent), a neurotoxic chemical warfare agent
  • VX (the team combat sport), a 21st century sport
  • ACES Colombia, a now-defunct airline, IATA code
  • vx, an airplane's best angle of climb airspeed; see V speeds
  • VX (videocassette format), an early consumer videocassette format produced by Panasonic
  • Virgin America IATA airline designator
  • Holden VX Commodore, a model of GM Holden's Commodore produced from 2000 to 2002
  • Para-Ski VX, a Canadian powered parachute design
  • RPG Maker VX, the latest (as of 2008) RPG Maker game