Voxel-based Morphometry - VBM For Brain Asymmetry

VBM For Brain Asymmetry

Usually VBM is performed for examining differences across subjects, but it may also be used to examine neuroanatomical differences between hemispheres detecting brain asymmetry. A technical procedure for such an investigation may use the following steps:

  1. Construction of a study-specific brain image template with a balanced set of left and right handed and males and females.
  2. Construction of white and grey matter templates from segmentation.
  3. Construction of symmetric grey and white matter templates by averaging right and left cerebral hemispheres.
  4. Segmentation and extraction of brain image, e.g., removal of scalp tissue in the image.
  5. Spatial normalization to the symmetric templates
  6. Correction for volume change (applying a Jacobian determinant)
  7. Spatial smoothing.
  8. Actual statistical analysis by the general linear model, i.e., statistical parametric mapping.

Read more about this topic:  Voxel-based Morphometry

Famous quotes containing the word brain:

    “I don’t know but a book in a man’s brain is better off than a book bound in calf—at any rate it is safer from criticism. And taking a book off the brain, is akin to the ticklish & dangerous business of taking an old painting off a panel—you have to scrape off the whole brain in order to get at it with due safety—& even then, the painting may not be worth the trouble.”
    —Herman Melville (1819–1891)