VBM For Brain Asymmetry
Usually VBM is performed for examining differences across subjects, but it may also be used to examine neuroanatomical differences between hemispheres detecting brain asymmetry. A technical procedure for such an investigation may use the following steps:
- Construction of a study-specific brain image template with a balanced set of left and right handed and males and females.
- Construction of white and grey matter templates from segmentation.
- Construction of symmetric grey and white matter templates by averaging right and left cerebral hemispheres.
- Segmentation and extraction of brain image, e.g., removal of scalp tissue in the image.
- Spatial normalization to the symmetric templates
- Correction for volume change (applying a Jacobian determinant)
- Spatial smoothing.
- Actual statistical analysis by the general linear model, i.e., statistical parametric mapping.
Read more about this topic: Voxel-based Morphometry
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