VLDL Receptor - Ligand Binding

Ligand Binding

VLDLR binds compounds containing apolipoprotein E (apoE). These ligands attach to the cysteine binding repeats in the N-terminus end. The difference in cysteine-rich repeats between the members of the LDL receptor family lead to the differences in binding affinity. VLDLR, in particular, binds VLDL and intermediate-density lipoprotein (IDL), but not LDL. This inability to bind LDL is due to VLDLR's incapability to bind apolipoprotein B (apoB), which is present in LDL.

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Famous quotes containing the word binding:

    Hate traps us by binding us too tightly to our adversary.
    Milan Kundera (b. 1929)