VLDL Receptor

VLDL Receptor

Identifiers Symbols VLDLR; CARMQ1; CHRMQ1; VLDLRCH External IDs OMIM: 192977 MGI: 98935 HomoloGene: 443 GeneCards: VLDLR Gene

Gene Ontology
Molecular function glycoprotein binding
low-density lipoprotein receptor activity
calcium ion binding
protein binding
very-low-density lipoprotein particle receptor activity
apolipoprotein binding
very-low-density lipoprotein particle binding
glycoprotein transporter activity
reelin receptor activity
calcium-dependent protein binding
Cellular component nucleus
plasma membrane
coated pit
cell surface
integral to membrane
very-low-density lipoprotein particle
apical part of cell
perinuclear region of cytoplasm
Biological process negative regulation of transcription from RNA polymerase II promoter
lipid transport
receptor-mediated endocytosis
signal transduction
nervous system development
heart development
response to nutrient
cholesterol metabolic process
ventral spinal cord development
cerebral cortex development
cellular response to insulin stimulus
glycoprotein transport
very-low-density lipoprotein particle clearance
reelin-mediated signaling pathway
cellular response to glucose starvation
response to drug
positive regulation of protein kinase activity
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to hypoxia
positive regulation of dendrite development
Sources: Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7436 22359 Ensembl ENSG00000147852 ENSMUSG00000024924 UniProt P98155 P98156 RefSeq (mRNA) NM_001018056.1 NM_001161420.1 RefSeq (protein) NP_001018066.1 NP_001154892.1 Location (UCSC) Chr 9:
2.62 – 2.65 Mb Chr 19:
27.22 – 27.25 Mb PubMed search

The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.

Read more about VLDL Receptor:  Protein Structure, Ligand Binding, Tissue Distribution and Expression, Associated Disorders

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