VLDL Receptor

VLDL Receptor

Identifiers Symbols VLDLR; CARMQ1; CHRMQ1; VLDLRCH External IDs OMIM: 192977 MGI: 98935 HomoloGene: 443 GeneCards: VLDLR Gene

Gene Ontology
Molecular function	• glycoprotein binding • low-density lipoprotein receptor activity • calcium ion binding • protein binding • very-low-density lipoprotein particle receptor activity • apolipoprotein binding • very-low-density lipoprotein particle binding • glycoprotein transporter activity • reelin receptor activity • calcium-dependent protein binding
Cellular component	• nucleus • plasma membrane • coated pit • cell surface • membrane • integral to membrane • very-low-density lipoprotein particle • apical part of cell • perinuclear region of cytoplasm
Biological process	• negative regulation of transcription from RNA polymerase II promoter • lipid transport • receptor-mediated endocytosis • signal transduction • nervous system development • heart development • response to nutrient • memory • cholesterol metabolic process • ventral spinal cord development • cerebral cortex development • cellular response to insulin stimulus • glycoprotein transport • very-low-density lipoprotein particle clearance • reelin-mediated signaling pathway • cellular response to glucose starvation • response to drug • positive regulation of protein kinase activity • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to hypoxia • positive regulation of dendrite development
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 7436 22359 Ensembl ENSG00000147852 ENSMUSG00000024924 UniProt P98155 P98156 RefSeq (mRNA) NM_001018056.1 NM_001161420.1 RefSeq (protein) NP_001018066.1 NP_001154892.1 Location (UCSC) Chr 9:
2.62 – 2.65 Mb Chr 19:
27.22 – 27.25 Mb PubMed search

The very-low-density-lipoprotein receptor (VLDLR) is a transmembrane lipoprotein receptor of the low-density-lipoprotein (LDL) receptor family. VLDLR shows considerable homology with the members of this lineage. Discovered in 1992 by T. Yamamoto, VLDLR is widely distributed throughout the tissues of the body, including the heart, skeletal muscle, adipose tissue, and the brain, but is absent from the liver. This receptor has an important role in cholesterol uptake, metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, and neuronal migration in the developing brain. In humans, VLDLR is encoded by the VLDLR gene. Mutations of this gene may lead to a variety of symptoms and diseases, which include type I lissencephaly, cerebellar hypoplasia, and atherosclerosis.