Vitamin K1 Deficiency
Vitamin K1-deficiency may occur by disturbed intestinal uptake (such as would occur in a bile duct obstruction), by therapeutic or accidental intake of a vitamin K1-antagonist such as coumadin, or, very rarely, by nutritional vitamin K1 deficiency. As a result, Gla-residues are inadequately formed and the Gla-proteins are insufficiently active.
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“It is easier to discover a deficiency in individuals, in states, and in Providence, than to see their real import and value.”
—Georg Wilhelm Friedrich Hegel (1770–1831)