Role in Multidrug Resistance
Vault RNAs, in conjunction with the vault ribonucleoprotein complex, have long been connected with drug resistance, though the mechanisms involved have only recently been determined. Vault non-coding RNAs produce small vault RNAs (svRNAs) through a DICER mechanism which then operate in similar manner to miRNAs: an svRNA binds an argonaute protein and downregulates expression of CYP3A4, an enzyme involved in drug metabolism.
Read more about this topic: Vault RNA
Famous quotes containing the words role and/or resistance:
“This [new] period of parenting is an intense one. Never will we know such responsibility, such productive and hard work, such potential for isolation in the caretaking role and such intimacy and close involvement in the growth and development of another human being.”
—Joan Sheingold Ditzion and Dennie Palmer (20th century)
“How is freedom measured, in individuals as in nations? By the resistance which has to be overcome, by the effort it costs to stay aloft. One would have to seek the highest type of free man where the greatest resistance is constantly being overcome: five steps from tyranny, near the threshold of the danger of servitude.”
—Friedrich Nietzsche (1844–1900)