Role in Multidrug Resistance
Vault RNAs, in conjunction with the vault ribonucleoprotein complex, have long been connected with drug resistance, though the mechanisms involved have only recently been determined. Vault non-coding RNAs produce small vault RNAs (svRNAs) through a DICER mechanism which then operate in similar manner to miRNAs: an svRNA binds an argonaute protein and downregulates expression of CYP3A4, an enzyme involved in drug metabolism.
Read more about this topic: Vault RNA
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