Role in Multidrug Resistance
Vault RNAs, in conjunction with the vault ribonucleoprotein complex, have long been connected with drug resistance, though the mechanisms involved have only recently been determined. Vault non-coding RNAs produce small vault RNAs (svRNAs) through a DICER mechanism which then operate in similar manner to miRNAs: an svRNA binds an argonaute protein and downregulates expression of CYP3A4, an enzyme involved in drug metabolism.
Read more about this topic: Vault RNA
Famous quotes containing the words role in, role and/or resistance:
“My role in society, or any artist or poet’s role, is to try and express what we all feel. Not to tell people how to feel. Not as a preacher, not as a leader, but as a reflection of us all.”
—John Lennon (1940–1980)
“Man, truly the animal that talks, is the only one that needs conversations to propagate its species.... In love conversations play an almost greater role than anything else. Love is the most talkative of all feelings and consists to a great extent completely of talkativeness.”
—Robert Musil (1880–1942)
“War is pillage versus resistance and if illusions of magnitude could be transmuted into ideals of magnanimity, peace might be realized.”
—Marianne Moore (1887–1972)