Vault RNA
Vault RNAs (vRNA, also known as vtRNA) are an RNA family found as part of the vault ribonucleoprotein complex first discovered in 1986. The complex consists of a major vault protein (MVP), two minor vault proteins (VPARP and TEP1), and several small untranslated RNA molecules. Each vault particle contains 8-16 vRNA molecules. The vault complex has been linked to drug resistance. Cryo-electron microscopy has revealed the vRNA resides internally close to the ends of the vault caps. The position of vRNA suggests that it could interact with both the interior and exterior of the vault particle. It has been shown that TEP1 is involved in stabilising the vRNA.
Read more about Vault RNA: Species Distribution, Role in Multidrug Resistance, See Also
Famous quotes containing the word vault:
“The constellated sounds
ran sprinkling on earth’s floor
As the dark vault above
with stars was spangled o’er.”
—Robert Bridges (1844–1930)