Function
In contrast to VEGF-A, VEGF-B plays a less pronounced role in the vascular system: Whereas VEGF-A is important for the formation of blood vessels, such as during development or in pathological conditions, VEGF-B seems to play a role only in the maintenance of newly formed blood vessels during pathological conditions. VEGF-B plays also an important role on several types of neurons. It is important for the protection of neurons in the retina and the cerebral cortex during stroke and of motoneurons during motor neuron diseases such as amyotrophic lateral sclerosis.
VEGF-B exerts its effects via the FLT1 receptor.
VEGF-B has also been found to control endothelial uptake and transport of fatty acids in heart and skeletal muscle.
Read more about this topic: Vascular Endothelial Growth Factor B
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