Valosin-containing Protein

Valosin-containing Protein

Identifiers Symbols VCP; ALS14; IBMPFD; TERA; p97 External IDs OMIM: 601023 MGI: 99919 HomoloGene: 5168 ChEMBL: 1075145 GeneCards: VCP Gene EC number 3.6.4.6

Gene Ontology
Molecular function • receptor binding
• protein binding
• ATP binding
• lipid binding
• ATPase activity
• protein phosphatase binding
• protein domain specific binding
• polyubiquitin binding
• protein complex binding
• identical protein binding
Cellular component • proteasome complex
• nucleus
• nucleolus
• cytoplasm
• endoplasmic reticulum
• cytosol
• site of double-strand break
• intracellular membrane-bounded organelle
Biological process • DNA repair
• double-strand break repair
• ER to Golgi vesicle-mediated transport
• activation of cysteine-type endopeptidase activity involved in apoptotic process
• response to DNA damage stimulus
• protein ubiquitination
• protein N-linked glycosylation via asparagine
• translesion synthesis
• ER-associated protein catabolic process
• endoplasmic reticulum unfolded protein response
• retrograde protein transport, ER to cytosol
• positive regulation of protein complex assembly
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• regulation of apoptotic process
• proteasomal ubiquitin-dependent protein catabolic process
• establishment of protein localization
• positive regulation of protein catabolic process
• protein homooligomerization
• aggresome assembly
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7415 269523 Ensembl ENSG00000165280 ENSMUSG00000028452 UniProt P55072 Q01853 RefSeq (mRNA) NM_007126 NM_009503 RefSeq (protein) NP_009057 NP_033529 Location (UCSC) Chr 9:
35.06 – 35.07 Mb Chr 4:
42.98 – 43 Mb PubMed search

Transitional endoplasmic reticulum ATPase (TER ATPase) also known as valosin-containing protein (VCP) is an enzyme that in humans is encoded by the VCP gene.

Read more about Valosin-containing Protein:  Function, Interactions, Clinical Significance

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