VAD may refer to:
- Vertebral artery dissection, the development of a flap-like tear in the vertebral artery
- Ventricular assist device, a mechanical circulatory device used to replace the function of a failing heart
- Vitamin A deficiency, a lack of vitamin A in humans
- Voice activity detection, a technique in which the presence or absence of human speech is detected
- Voice-Activated Dialling, the use of speech recognition to identify the destination for a telephone call
- Voluntary Aid Detachment, a voluntary organisation providing field nursing services in the British Empire
- Vincristine, Adriamycin (doxorubicin), Dexamethasone; a chemotherapy regimen used for multiple myeloma
See also Vad (disambiguation).