Plot
When the scientists are operating on the guard, a headcrab bursts from his chest cavity (coupled with the Nostromo look of the USS Darkstar, this was most likely also inspired by Alien) forcing the scientists to activate the incinerator. The flame jet kills the headcrab but also detonates a fuel canister, which creates a chain reaction.
This causes a surge which badly damages the USS Darkstar's main computer, deactivating all the force fields and letting loose the aliens. The aliens kill most of the crew, but Freeman manages to reach an escape pod and escape the ship, shortly before it explodes. The game ends with Freeman's pod heading towards the nearby planet, pursued by a large alien vessel.
At least one other scientist also survived the destruction of the USS Darkstar. During Freeman's entering of the labs, the escape pod elevator can be seen through the window, down which the scientist is heading. When reaching the escape pod launch room, one escape pod has already been launched.
Read more about this topic: USS Darkstar
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“The plot was most interesting. It belonged to no particular age, people, or country, and was perhaps the more delightful on that account, as nobody’s previous information could afford the remotest glimmering of what would ever come of it.”
—Charles Dickens (1812–1870)
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—Mark Twain [Samuel Langhorne Clemens] (1835–1910)
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—Ralph Waldo Emerson (1803–1882)