Usp8

USP8

Identifiers Symbols USP8; HumORF8; UBPY External IDs OMIM: 603158 MGI: 1934029 HomoloGene: 3782 GeneCards: USP8 Gene EC number 3.4.19.12

Gene Ontology
Molecular function	• cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • ubiquitin-specific protease activity • protein binding • SH3 domain binding
Cellular component	• nucleus • cytoplasm • early endosome • cytosol • endosome membrane • extrinsic to plasma membrane • midbody
Biological process	• cytokinesis after mitosis • ubiquitin-dependent protein catabolic process • endosome organization • Ras protein signal transduction • cell proliferation • protein deubiquitination • protein K63-linked deubiquitination • protein K48-linked deubiquitination
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 9101 84092 Ensembl ENSG00000138592 ENSMUSG00000027363 UniProt P40818 Q80U87 RefSeq (mRNA) NM_001128610 NM_001252580 RefSeq (protein) NP_001122082 NP_001239509 Location (UCSC) Chr 15:
50.72 – 50.79 Mb Chr 2:
126.71 – 126.76 Mb PubMed search

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.