UPB may refer to:
- UPB (holding) - U. Pilena Birojs, construction firm in Liepāja, Latvia
- Unclassified Personal Beliefs
- Union of Poles in Belarus
- Unique Perceived Benefit
- University POLITEHNICA of Bucharest
- University of Paderborn
- University of Pittsburgh at Bradford
- Universidad Pontificia Bolivariana
- Universal powerline bus
- Universally preferable behaviour
- Unpaid Principal Balance (a financial term)
- Utah Premiere Brass
- Uttar Prdesh Board