Clinical Significance
Abnormalities within the fiber bundles of the uncinate fasciculus associate with social anxiety, Alzheimer's disease, bipolar disorder, and depression in the elderly that had first had it in adolescence or early adulthood.
Such abnormalities also link to schizophrenia, In those with schizotypal personality disorder, reduced fractional anisotropy in the right uncinate fasciculus associates personality traits and clinical symptoms of ideas of reference, suspiciousness, restricted affect, reduced extraversion and social anxiety, while those on the left side associate with general intelligence, verbal and visual memory, and executive performance. The greater left than right fractional anisotropy of the uncinate fasciculus is missing in those with schizophrenia.
In 2009 it was implicated in psychopathy—individuals with a high score in the Psychopathy Checklist Revised and an associated history of violent behavior appeared to have abnormalities in it.
Read more about this topic: Uncinate Fasciculus
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