Clinical Significance
Abnormalities within the fiber bundles of the uncinate fasciculus associate with social anxiety, Alzheimer's disease, bipolar disorder, and depression in the elderly that had first had it in adolescence or early adulthood.
Such abnormalities also link to schizophrenia, In those with schizotypal personality disorder, reduced fractional anisotropy in the right uncinate fasciculus associates personality traits and clinical symptoms of ideas of reference, suspiciousness, restricted affect, reduced extraversion and social anxiety, while those on the left side associate with general intelligence, verbal and visual memory, and executive performance. The greater left than right fractional anisotropy of the uncinate fasciculus is missing in those with schizophrenia.
In 2009 it was implicated in psychopathy—individuals with a high score in the Psychopathy Checklist Revised and an associated history of violent behavior appeared to have abnormalities in it.
Read more about this topic: Uncinate Fasciculus
Famous quotes containing the word significance:
“The hypothesis I wish to advance is that ... the language of morality is in ... grave disorder.... What we possess, if this is true, are the fragments of a conceptual scheme, parts of which now lack those contexts from which their significance derived. We possess indeed simulacra of morality, we continue to use many of the key expressions. But we have—very largely if not entirely—lost our comprehension, both theoretical and practical, of morality.”
—Alasdair Chalmers MacIntyre (b. 1929)