UCK2

UCK2

Identifiers Symbols UCK2; TSA903; UK; UMPK External IDs OMIM: 609329 MGI: 1931744 HomoloGene: 40850 ChEMBL: 2469 GeneCards: UCK2 Gene EC number 2.7.1.48

Gene Ontology
Molecular function	• uridine kinase activity • ATP binding • phosphotransferase activity, alcohol group as acceptor • nucleoside kinase activity
Cellular component	• cellular_component • cytosol • intracellular membrane-bounded organelle
Biological process	• pyrimidine nucleobase metabolic process • feeding behavior • pyrimidine nucleoside salvage • UMP salvage • CTP salvage • small molecule metabolic process • response to axon injury • nucleobase-containing small molecule metabolic process • cellular response to oxygen levels
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7371 80914 Ensembl ENSG00000143179 ENSMUSG00000026558 UniProt Q9BZX2 Q99PM9 RefSeq (mRNA) NM_012474 NM_030724 RefSeq (protein) NP_036606 NP_109649 Location (UCSC) Chr 1:
165.8 – 165.88 Mb Chr 1:
167.23 – 167.29 Mb PubMed search

Uridine-cytidine kinase 2 is an enzyme that in humans is encoded by the UCK2 gene.

The protein encoded by this gene catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively. This is the first step in the production of the pyrimidine nucleoside triphosphates required for RNA and DNA synthesis. In addition, an allele of this gene may play a role in mediating nonhumoral immunity to Hemophilus influenzae type B.