Through-space Correlation Methods
These methods establish correlations between nuclei which are physically close to each other regardless of whether there is a bond between them. They use the Nuclear Overhauser effect (NOE) by which nearby atoms (within about 5 Å) undergo cross relaxation by a mechanism related to spin–lattice relaxation.
Read more about this topic: Two-dimensional Nuclear Magnetic Resonance Spectroscopy
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“Cold and hunger seem more friendly to my nature than those methods which men have adopted and advise to ward them off.”
—Henry David Thoreau (18171862)