TRIM5alpha

TRIM5alpha

Identifiers Symbols TRIM5; RNF88; TRIM5alpha External IDs OMIM: 608487 MGI: 2441735 HomoloGene: 75345 GeneCards: TRIM5 Gene EC number 6.3.2.-

Gene Ontology
Molecular function	• protein binding • zinc ion binding • ligase activity • identical protein binding • protein homodimerization activity
Cellular component	• cytoplasmic mRNA processing body • cytoplasm
Biological process	• response to virus • protein ubiquitination • virus-host interaction • protein trimerization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 85363 319236 Ensembl ENSG00000132256 ENSMUSG00000057143 UniProt Q9C035 D3Z3L3 RefSeq (mRNA) NM_033034.2 NM_001146007.1 RefSeq (protein) NP_149023.2 NP_001139479.1 Location (UCSC) Chr 11:
5.68 – 5.96 Mb Chr 7:
104.34 – 104.35 Mb PubMed search

Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene. The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection.

TRIM5α is composed of 493 amino acids that is found in the cells of most primates. TRIM5α is an intrinsic immune factor important in the innate immune defense against retroviruses, along with the APOBEC family of proteins, tetherin and TRIM22.