Trim5alpha

TRIM5alpha

Identifiers Symbols TRIM5; RNF88; TRIM5alpha External IDs OMIM: 608487 MGI: 2441735 HomoloGene: 75345 GeneCards: TRIM5 Gene EC number 6.3.2.-

Gene Ontology
Molecular function	• protein binding • zinc ion binding • ligase activity • identical protein binding • protein homodimerization activity
Cellular component	• cytoplasmic mRNA processing body • cytoplasm
Biological process	• response to virus • protein ubiquitination • virus-host interaction • protein trimerization
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 85363 319236 Ensembl ENSG00000132256 ENSMUSG00000057143 UniProt Q9C035 D3Z3L3 RefSeq (mRNA) NM_033034.2 NM_001146007.1 RefSeq (protein) NP_149023.2 NP_001139479.1 Location (UCSC) Chr 11:
5.68 – 5.96 Mb Chr 7:
104.34 – 104.35 Mb PubMed search

Tripartite motif-containing protein 5 also known as RING finger protein 88 is a protein that in humans is encoded by the TRIM5 gene. The alpha isoform of this protein, TRIM5α, is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection.