Trejo is a surname, and may refer to:
Origin of Surname: This surname originated in Spain in the region of Extremadura. During the Spanish colonial empire of the Americas many people with this surname immigrated to the region. Among the first settlers were Hernando de Trejo and Juan de Trejo who arrived in the Spanish Empire in 1513. Diego Lorenzo de Trejo settled in New Spain in 1577.
- Arnulfo Trejo (1922 – 2002), American writer and professor
- Danny Trejo (born 1944), American film actor
- Germán Trejo, Mexican American activist
- José Luis Trejo (born 1951), Mexican football coach
- Lucas Trejo (born 1987), Argentine football player
- Mario Trejo (born 1926), Argentine poet, playwright, screenwriter and journalist
- Óscar Trejo (born 1988), Argentine footballer
- Stephen Trejo (born 1977), American football player
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