Transthyretin

Transthyretin

Identifiers Symbols TTR; CTS; CTS1; HsT2651; PALB; TBPA External IDs OMIM: 176300 MGI: 98865 HomoloGene: 317 ChEMBL: 3194 GeneCards: TTR Gene

Gene Ontology
Molecular function	• hormone activity • protein binding • hormone binding
Cellular component	• extracellular region • extracellular space • cytoplasm
Biological process	• transport
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7276 22139 Ensembl ENSG00000118271 ENSMUSG00000061808 UniProt P02766 P07309 RefSeq (mRNA) NM_000371.3 NM_013697.5 RefSeq (protein) NP_000362.1 NP_038725.1 Location (UCSC) Chr 18:
29.17 – 29.18 Mb Chr 18:
20.67 – 20.67 Mb PubMed search

Transthyretin (TTR) is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol binding protein bound to retinol. This is how transthyretin gained its name, transports thyroxine and retinol. The liver secretes transthyretin into the blood, and the choroid plexus secretes TTR into the cerebrospinal fluid.

TTR was originally called prealbumin (or Thyroxine-binding prealbumin) because it ran faster than albumin on electrophoresis gels.