Transient Acantholytic Dermatosis - Treatment

Treatment

The most important thing about Grover's disease treatment is to remain cool, as further sweating will induce more itchy spots. However, lesions aggravated by sweat usually return to "normal" fairly quickly—avoiding sweat is not a reason to avoid exercise. Minor outbreaks can be controlled with prescription strength topical cortisone creams. More troubling eruptions usually clear up after treatment for one to three months with Accutane or tetracycline. If these fail or the outbreak is severe, PUVA phototherapy treatments, antifungal pills and cortisone injections are alternatives.

A further treatment option is a cream of zinc oxide, talc, and glycerol. This cream helps with the itching and promotes faster healing. In France, where it is available over the counter (OTC), the zinc oxide, talc, and glycerol cream is branded as Aloplastine.

Although the cause of Grover's is unknown, it may arise in quite dry skin. Many affected individuals are sun damaged.

Some research has suggested a correlation of Grover's disease with mercury toxicity in which Chemet may help.

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