TPH1

TPH1

Identifiers Symbols TPH1; TPRH; TRPH External IDs OMIM: 191060 MGI: 98796 HomoloGene: 121565 ChEMBL: 5689 GeneCards: TPH1 Gene EC number 1.14.16.4

Gene Ontology
Molecular function	• tryptophan 5-monooxygenase activity • iron ion binding • amino acid binding
Cellular component	• cytosol • neuron projection
Biological process	• circadian rhythm • aromatic amino acid family metabolic process • negative regulation of ossification • cellular nitrogen compound metabolic process • response to immobilization stress • serotonin biosynthetic process • small molecule metabolic process • indolalkylamine biosynthetic process • bone remodeling • mammary gland alveolus development
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7166 21990 Ensembl ENSG00000129167 ENSMUSG00000040046 UniProt P17752 P17532 RefSeq (mRNA) NM_004179 NM_001136084 RefSeq (protein) NP_004170 NP_001129556 Location (UCSC) Chr 11:
18.04 – 18.06 Mb Chr 7:
46.65 – 46.67 Mb PubMed search

Tryptophan hydroxylase 1 (tryptophan 5-monooxygenase), also known as TPH1, is an enzyme which in humans is encoded by the TPH1 gene.

Until 2003 it was thought that there only was a single TPH gene, but then a second form was found in the mouse (Tph2), rat and human brain (TPH2) and the original Tph/TPH was then renamed to Tph1/TPH1.