Tnks

TNKS

Identifiers Symbols TNKS; ARTD5; PARP-5a; PARP5A; PARPL; TIN1; TINF1; TNKS1; pART5 External IDs OMIM: 603303 MGI: 1341087 HomoloGene: 18405 ChEMBL: 6164 GeneCards: TNKS Gene EC number 2.4.2.30

Gene Ontology
Molecular function	• NAD+ ADP-ribosyltransferase activity • protein binding • zinc ion binding
Cellular component	• Golgi membrane • pericentriolar material • chromosome, centromeric region • chromosome, telomeric region • nuclear chromosome, telomeric region • spindle pole • nuclear pore • Golgi apparatus • nuclear membrane
Biological process	• protein polyubiquitination • protein ADP-ribosylation • mitotic spindle organization • mitosis • protein transport • Wnt receptor signaling pathway • peptidyl-serine phosphorylation • peptidyl-threonine phosphorylation • regulation of telomere maintenance via telomerase • positive regulation of telomere maintenance via telomerase • negative regulation of DNA binding • positive regulation of transcription from RNA polymerase II promoter • mRNA transport • spindle assembly • cell division • protein localization to chromosome, telomeric region • protein poly-ADP-ribosylation • protein auto-ADP-ribosylation • positive regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8658 21951 Ensembl ENSG00000173273 ENSMUSG00000031529 UniProt O95271 Q6PFX9 RefSeq (mRNA) NM_003747 NM_175091 RefSeq (protein) NP_003738 NP_780300 Location (UCSC) Chr 8:
9.41 – 9.64 Mb Chr 8:
34.83 – 34.97 Mb PubMed search

Tankyrase-1 is an enzyme that in humans is encoded by the TNKS gene.