Cast
- Aaron Eckhart as Dr. Joshua "Josh" Keyes, a scientist who designs the navigation system for Virgil and is assigned as head of the project.
- Hilary Swank as Major Rebecca "Beck" Childs, USAF, an astronaut who distinguished herself during an emergency crash landing of the Space Shuttle Endeavour in Los Angeles, California.
- Delroy Lindo as Dr. Edward "Braz" Brazzelton, the designer of Virgil and the ultrasonic laser.
- Stanley Tucci as Dr. Conrad Zimsky, Earth specialist and designer of Project D.E.S.T.I.N.I..
- Tchéky Karyo as Dr. Serge Leveque, nuclear weapons specialist.
- Bruce Greenwood as Commander Robert "Bob" Iverson, USN, Major Childs' commander and mentor.
- DJ Qualls as Theodore Donald "Rat" Finch, a computer hacker who is widely regarded as the best in the world, crippled the FBI's database, recruited to control the flow of information on the Internet to prevent public panic.
- Alfre Woodard as Flight Commander Dr. Talma "Stick" Stickley, the mission commander for NASA Space Shuttle Endeavour and Virgil.
- Richard Jenkins as Lieutenant General Thomas Purcell, a lieutenant general in the United States army and leader of the operation.
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