Regular Cast
- Bernie McCullough (himself) — The show's main protagonist who is loosely based upon the late comedian of the same name. Bernie and his wife took in the three kids when their drug-addled mother, his sister Stacy, was no longer able to be a proper parent. Bernie uses tough-love parenting tactics and he can be both strict and comical. He narrates the series, and between scenes he talks to the audience by addressing them as "America." Although he loves all three kids, his favorite is Bryana (whom he affectionately calls "Baby Girl" because she is the youngest). He always finds himself going head to head with teenage Vanessa, the eldest sibling, whose poor attitude always gives him a hard time.
- Wanda "Baby" McCullough (Kellita Smith) — Bernie's loving wife, a very intelligent woman who is VP for AT&T. She loves raising the kids with Bernie but periodically her patience is tested. Whenever Bernie has a problem, she does her best to help, though her assistance can be stubbornly overbearing and unnecessary at times. She plays a minor role in the series finale.
- Bryana "Baby Girl" Thomkins (Dee Dee Davis) — Bernie and Wanda's younger niece, the youngest child and the half-sister of Jordan and Vanessa. Bryana is a friendly little girl who is sweet, innocent, and quite naive, though she sometimes turns more bratty as the series progesses. Bryana is Bernie's favorite (although he loves all three). Bryana is playful and always trusts her Uncle Bernie. One of her favorite TV characters was Drooby (a parody of Barney) until she found out that he was only a man in a costume (David Faustino in a guest role). Bryana is known for always attacking and successfully beating up her older brother Jordan.
- Jordan Thomkins (Jeremy Suarez) — Bernie and Wanda's nephew, the middle child. Jordan is very nerdy and peculiar. He is interested in collecting bugs and conducting odd science experiments. He is always getting beat up by his little sister, Bryana; though on very minor occasions, he has been able to scare her in retaliation and make her cry. Early on in the series, Jordan would always cry and urinate on himself. As the series progressed, he gets tougher and more masculine. He took an interest in magic and even began trying to date girls. Although he knows that there is nothing wrong with Jordan, Bernie tries to his best to make him more masculine.
- Vanessa "Nessa" Thomkins (Camille Winbush) — Bernie and Wanda's elder niece, the eldest of the three children, and the show's main antagonist. Vanessa always purposely gives Bernie a hard time with her nasty attitude, but most of this attitude comes from the pressure of being the eldest and having to take the parent role with her younger siblings. As the series progresses, she gets along better with Bernie and matures into a young woman preparing for college. In the final season, she spends most of her time trying to find the perfect college and rejecting Bernie's help with that.
Read more about this topic: The Bernie Mac Show
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