Thacker is a surname that may refer to:
- Blaine Thacker (born 1941), Canadian politician from Alberta; member of parliament 1979–93
- Brian Miles Thacker (born 1945), American army officer; recipient of the Medal of Honor for action during the Vietnam war
- Cathy Gillen Thacker (contemporary), American author of romance novels
- Charles P. Thacker (born 1943), American computer pioneer
- D. D. Thacker (1884-1961), Indian coal miner and philanthropist.
- Gail Thacker (contemporary), avant-garde photographer and theater manager
- Henry Thacker (1870–1939), New Zealand physician and politician; member of Parliament 1914–22
- Herbert Cyril Thacker (1870–1953), Canadian army general; Chief of the General Staff 1927–29
- Julie Thacker (contemporary), American television writer
- Lawrence Thacker, rugby league footballer of the 1930s and 1940s for England, and Hull
- Paul D. Thacker (contemporary), American journalist in medical topics
- Ralph Thacker (1880–after 1915), American college football coach
- Robert E. Thacker (born 1918), American test pilot and model aircraft enthusiast
- Tab Thacker (1962–2007), American collegiate wrestler and actor
- Tom Thacker (singer) (born 1978), Canadian punk rock singer
- Tom Thacker (born 1939), American professional basketball player
- Tony Thacker (contemporary), American museum director and writer
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