Substance
Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. Powders and aerosols may all take advantage of this method. However, a number of factors, such as pH, molecular weight, and lipid solubility, may determine whether the route is practical. Based on these properties, a suitably soluble drug may diffuse too slowly through the mucosa to be effective. However, many drugs are much more potent taken sublingually, and it is generally a safer alternative than administration via the nasal mucosa. Many people are forced by the high cost of pharmaceuticals to split their pills and take them sublingually. One drawback, however, is tooth discoloration and decay caused by long-term use of this method with acidic or otherwise caustic drugs and fillers.
Read more about this topic: Sublingual Administration
Famous quotes containing the word substance:
“Leave everything. Leave Dada. Leave your wife. Leave your mistress. Leave your hopes and fears. Leave your children in the woods. Leave the substance for the shadow. Leave your easy life, leave what you are given for the future. Set off on the roads.”
—André Breton (1896–1966)
“But they that hold God to be [an incorporeal substance] ... do absolutely make God to be nothing at all. But how? Were they atheists? No. For though by ignorance of the consequence they said that which was equivalent to atheism, yet in their hearts they thought God a substance ... So that this atheism by consequence is a very easy thing to be fallen into, even by the most godly men of the church.”
—Thomas Hobbes (1588–1679)
“I do not remember anything which Confucius has said directly respecting man’s “origin, purpose, and destiny.” He was more practical than that. He is full of wisdom applied to human relations,—to the private life,—the family,—government, etc. It is remarkable that, according to his own account, the sum and substance of his teaching is, as you know, to do as you would be done by.”
—Henry David Thoreau (1817–1862)