Substance
Almost any form of substance may be amenable to sublingual administration if it dissolves easily in saliva. Powders and aerosols may all take advantage of this method. However, a number of factors, such as pH, molecular weight, and lipid solubility, may determine whether the route is practical. Based on these properties, a suitably soluble drug may diffuse too slowly through the mucosa to be effective. However, many drugs are much more potent taken sublingually, and it is generally a safer alternative than administration via the nasal mucosa. Many people are forced by the high cost of pharmaceuticals to split their pills and take them sublingually. One drawback, however, is tooth discoloration and decay caused by long-term use of this method with acidic or otherwise caustic drugs and fillers.
Read more about this topic: Sublingual Administration
Famous quotes containing the word substance:
“Ah, to build, to build!
That is the noblest art of all the arts.
Painting and sculpture are but images,
Are merely shadows cast by outward things
On stone or canvas, having in themselves
No separate existence. Architecture,
Existing in itself, and not in seeming
A something it is not, surpasses them
As substance shadow.”
—Henry Wadsworth Longfellow (1807–1882)
“True, I talk of dreams,
Which are the children of an idle brain,
Begot of nothing but vain fantasy,
Which is as thin of substance as the air,
And more inconstant than the wind, who woos
Even now the frozen bosom of the north,
And being angered, puffs away from thence,
Turning his side to the dew-dropping south.”
—William Shakespeare (1564–1616)
“Strong be thy wallis that about the standis;
Wise be the people that within the dwellis;
Fresh is thy ryver with his lusty strandis;
Blith be thy chirches, wele sownyng be thy bellis;
Riche be thy merchauntis in substance that excellis
Fair be thy wives, right lovesom, white and small;
Clere be thy virgyns, lusty under kellis:
London, thou art the flour of Cities all.”
—William Dunbar (c. 1465–c. 1530)