Subgranular Zone - Clinical Significance

Clinical Significance

There are many neurological diseases and disorders that exhibit changes in neurogenesis in the SGZ. However, the mechanisms and significances of these changes are still not fully understood. For example, patients with Parkinson's disease and Alzheimer's disease generally exhibit a decrease in cell proliferation, which is expected. However, those who experience epilepsy, a stroke, or inflammation exhibit increases in neurogenesis, possible evidence of attempts by the brain to repair itself. Further definition of the mechanisms and consequences of these changes may lead to new therapies for these neurological disorders. Insights into neurogenesis in the SGZ may also provide clues in understanding the underlying mechanisms of cancer, since cancer cells exhibit many of the same characteristics of undifferentiated, proliferating precursor cells in the SGZ. Separation of precursor cells from the regulatory microenvironment of the SGZ may be a factor in the formation of cancerous tumors.