Comparison To Other Classification Systems
This classification is more significantly based on the human expertise than semi-automatic CATH, its chief rival. Human expertise is needed to decide whether certain proteins are evolutionary related and therefore should be assigned to the same superfamily, or their similarity is a result of structural constraints and therefore they belong to the same fold. Another database, FSSP, is purely automatically generated (including regular automatic updates) but offers no classification, allowing the user to draw their own conclusion as to the significance of structural relationships based on the pairwise comparisons of individual protein structures.
Read more about this topic: Structural Classification Of Proteins Database
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