Structural Classification Of Proteins Database
The Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their structures and amino acid sequences. A motivation for this classification is to determine the evolutionary relationship between proteins. Proteins with the same shapes but having little sequence or functional similarity are placed in different "superfamilies", and are assumed to have only a very distant common ancestor. Proteins having the same shape and some similarity of sequence and/or function are placed in "families", and are assumed to have a closer common ancestor.
The SCOP database is freely accessible on the internet. SCOP was created in 1994. It is maintained by Alexei G. Murzin and his colleagues at the Laboratory of Molecular Biology in Cambridge, England. As of September 2012, the current version of SCOP is 1.75 (released June 2009). A snapshot of the next release of SCOP, which is called pre-SCOP (for preview), is accessible from the main SCOP page.
Read more about Structural Classification Of Proteins Database: Hierarchical Structure, Example, Comparison To Other Classification Systems, Wikilinks To SCOP
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