Statistical coupling analysis or SCA is a technique used in bioinformatics to measure covariation between pairs of amino acids in a protein multiple sequence alignment (MSA). More specifically, it quantifies how much the amino acid distribution at some position i changes upon a perturbation of the amino acid distribution at another position j. The resulting statistical coupling energy indicates the degree of evolutionary dependence between the residues, with higher coupling energy corresponding to increased dependence.
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Famous quotes containing the words coupling and/or analysis:
“The time of the seasons and the constellations
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The time of the coupling of man and woman
And that of beasts. Feet rising and falling.
Eating and drinking. Dung and death.”
—T.S. (Thomas Stearns)
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—Alice Foote MacDougall (1867–1945)