STAT3

STAT3

Identifiers Symbols STAT3; APRF; HIES External IDs OMIM: 102582 MGI: 103038 HomoloGene: 7960 ChEMBL: 4026 GeneCards: STAT3 Gene

Gene Ontology
Molecular function	• RNA polymerase II repressing transcription factor binding • DNA binding • sequence-specific DNA binding transcription factor activity • signal transducer activity • ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity • calcium ion binding • protein binding • transcription factor binding • protein kinase binding • CCR5 chemokine receptor binding • glucocorticoid receptor binding • sequence-specific DNA binding • transcription regulatory region DNA binding • protein dimerization activity
Cellular component	• nucleus • nucleoplasm • nucleolus • cytoplasm • cytosol • plasma membrane
Biological process	• negative regulation of transcription from RNA polymerase II promoter • temperature homeostasis • eye photoreceptor cell differentiation • regulation of transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • protein import into nucleus • cellular component movement • acute-phase response • signal transduction • JAK-STAT cascade • nervous system development • cell proliferation • virus-host interaction • cytokine-mediated signaling pathway • stem cell maintenance • sexual reproduction • intracellular receptor signaling pathway • response to estradiol stimulus • cellular response to hormone stimulus • regulation of multicellular organism growth • response to drug • glucose homeostasis • eating behavior • response to ethanol • positive regulation of Notch signaling pathway • positive regulation of transcription, DNA-dependent • positive regulation of transcription from RNA polymerase II promoter • neurotrophin TRK receptor signaling pathway • astrocyte differentiation • radial glial cell differentiation • growth hormone receptor signaling pathway • JAK-STAT cascade involved in growth hormone signaling pathway • interleukin-6-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 6774 20848 Ensembl ENSG00000168610 ENSMUSG00000004040 UniProt P40763 P42227 RefSeq (mRNA) NM_003150 NM_011486 RefSeq (protein) NP_003141 NP_035616 Location (UCSC) Chr 17:
40.47 – 40.54 Mb Chr 11:
100.89 – 100.94 Mb PubMed search

Signal transducer and activator of transcription 3, also known as STAT3, is a transcription factor which in humans is encoded by the STAT3 gene.