SRE can refer to:
- Sancta Romana Ecclesia (S.R.E.) ("The Holy Roman Church"), often used in reference to the College of Cardinals of the Roman Catholic Church.
- Secretaría de Relaciones Exteriores, the foreign ministry of Mexico.
- Swinging Radio England, a former commercial pirate radio station
- Sempra Energy, a company with New York Stock Exchange symbol SRE
- Samenwerkingsverband Regio Eindhoven, a city region in The Netherlands
In science and technology:
- Serious Reportable Event, an inexcusable outcome in a health care setting.
- Serum Response Element; see Serum response factor
- Steroid Response Element
- Site Reliability Engineering, a branch of reliability engineering applied to websites.
- Space Capsule Recovery Experiment, an Indian satellite
- Sodium Reactor Experiment, a former US experimental nuclear power plant
- Juana Azurduy de Padilla International Airport, in Sucre, Bolivia, which has IATA airport code SRE
- Saharanpur station, an Indian railway station with Indian railway code SRE
- Stranraer Harbour (Ship), a UK railway station with UK railway station code SRE
- Solar Realms Elite, a multi-player game
- Seychellois rupee, the currency of the Seychelles
- Sre, a Bahnaric language
- Sex and Relationships Education a form of sex education taught in the UK