Spira may refer to:
People:
- Chaim Elazar Spira, Munkacs Rebbe
- Elijah Spira
- Fred Spira (1924–2007), Innovator and Executive in the Photographic Industry
- Harry Spira
- Jonathan Spira
- Julie Spira, author
- Nathan Nata Spira
- Phyllis Spira, South African prima ballerina assoluta
- Thomas Spira (1923–2005), Professor Emeritus of History at the University of Prince Edward Island
- Joel Spira, actor
Other uses:
- The medieval and Yiddish-Hebrew name of Speyer (שפירא), Germany
- Spira (Final Fantasy), the world in which the role-playing video games Final Fantasy X and Final Fantasy X-2 are based
- Spira mirabilis, the mathematical logarithmic spiral
- Spira Footwear, a U.S. manufacturer of athletic shoes
- Cadbury Spira, a Cadbury chocolate bar in a helix shape
- Spira (bryozoan), an extinct genus of cryptostome Bryozoan
- Spira (car)