Complex Components
The sorting and assembly machinery is made up of three subunits, Sam35, Sam37 and Sam50, of which Sam50 is embedded within the outer mitochondrial membrane. Both Sam35 and Sam37 are located on the cytosolic face of the SAM complex are peripheral membrane proteins that are not essential for survival. Sam35 is believed to bind to substrate proteins, while Sam37 acts after Sam35 to stimulate release of the substrate protein from the SAM complex.
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