Chemistry
Thiopental, 5-ethyl-5-(1-methylbutyl)2-thiobarbituric acid, is synthesized by the alkylation of ethylmalonic ester with 2-bromopentane in the presence of sodium ethoxide. The product ethyl-(1-methylbutyl)malonic ester undergoes heterocyclization with thiourea, using sodium ethoxide as a base.
- E.H. Volwlier, D.L. Tabern, U.S. Patent 2,153,729 (1939).
- G.H. Donaldson, W. Bay, U.S. Patent 2,876,225 (1959).
Read more about this topic: Sodium Thiopental
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