SKL can stand for:
- Finnish Christian League (Suomen Kristillinen Liitto)
- Süddeutsche Klassenlotterie (a German lottery)
- Seekriegsleitung or "Naval Warfare Command", which led the German Navy during the First World War.
- Simple Key Loader, officially designated the AN/PYQ-10 fill device.
- Statens kriminaltekniska laboratorium
- Slovenska košarkarska liga, Slovene for Slovenian Basketball League
- School for Kids In Laos, a Canadian non for profit organisation which raises money to build schools in impoverished Laos
- SKL (biochemistry), a peroxisome targeting signal involved in Protein targeting
- Strawberry kiwi lemonade, a Turkey Hill brand drink