Simonis is also a surname or given name, and may refer to:
- Simonis Palaiologina, Byzantine princess and third wife of Stefan Uroš II Milutin of Serbia
- Simonis de Kéza, chronicler
- Simonis Starovolsci, Polish scholar
- Adolphe Dominique Florent Joseph Simonis, French dramatist, named further Empis
- Adrianus Johannes Simonis, Dutch Roman Catholic Cardinal and former Archbishop of Utrecht
- Eugène Simonis or Eugen Simonis, Belgian sculptor and architect
- Heide Simonis, German politician
- Kazys Simonis, Lithuanian artist